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5月16日 Paul E. Floreancig教授学术报告(化学与材料科学学院)

编辑:时间:2019-05-10浏览:85设置

报告人:Paul E. Floreancig教授,美国匹兹堡大学

报告题目:Natural Product Synthesis as an Inspiration for Method Development and Biological Studies

报告时间:516日(周 四)下午4:10

报告地点:化学与材料科学学院211

主办单位:化学与材料科学学院、科研院

  

Paul E. Floreancig,美国匹兹堡大学教授。1986年于印第安纳大学获得学士学位,1989年于耶鲁大学获得硕士学位,1997年于斯坦福大学获得博士学位,1997-1999年于加州理工学院从事博士后研究。1999-2010年于匹兹堡大学先后担任助理教授、副教授,2010年担任匹兹堡大学教授。主要研究兴趣为天然产物全合成、药物化学、合成方法学。


近年代表性论文:

1) Caplan, S. M.; Floreancig, P. E. Total Synthesis of Divergolides E and H Angew. Chem., Int. Ed. 2018, 57, 15866-15870. DOI: 10.1002/anie.201810336.

2) Qin, Q.; Xie, Y.; Floreancig, P. E. Diarylmethane Synthesis through Re2O7-Catalyzed Bimolecular Dehydrative Friedel–Crafts Reactions Chem. Sci. 2018, 9, 8528-8534. DOI: 10.1039/C8SC03570A.

3) Morales-Rivera, C. A.; Floreancig, P. E.; Liu, P. Predictive Model for Oxidative C–H Functionalization Reactivity with 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone J. Am. Chem. Soc. 2017, 139, 17935-17944. DOI: 10.1021/jacs.7b08902.

4) Rohrs, T. M.; Qin, Q.; Floreancig, P. E. Re2O7-Mediated Dehydrative Cyclization Reactions: Application to the Total Synthesis of Herboxidiene and an Analog Angew. Chem., Int. Ed. 2017, 56, 10900-10904. DOI: 10.1002/anie.201705924.

5) Hanna, R. D.; Naro, Y.; Deiters, A.; Floreancig, P. E. Alcohol, Aldehyde, and Ketone Liberation and Intracellular Cargo Release through Peroxide-Mediated Boryl Ether Fragmentation J. Am. Chem. Soc. 2016, 138, 13353-13360. DOI: 10.1021/jacs.6b07890.

6) Han, X.; Floreancig, P. E. Spiroacetal Formation through Telescoped Cycloaddition and Carbon–Hydrogen Bond Functionalization: Total Synthesis of Bistramide A Angew. Chem., Int. Ed. 2014, 53, 11075-11078. DOI: 10.1002/anie.201406819.

7) Xie, Y.; Floreancig, P. E. Allylic Alcohol Transposition-Based Heterocycle Synthesis Using Traceless Trapping Groups Angew. Chem., Int. Ed. 2014, 53, 4926-4929. DOI: 10.1002/anie201402010.

8) Xie, Y.; Floreancig, P. E. Cascade Approach to Stereoselective Polycyclic Ether Formation: Epoxides as Trapping Agents in the Transposition of Allylic Alcohols Angew. Chem., Int. Ed. 2013, 52, 625-628. DOI: 10.1002/anie.201208132.


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